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- Title
Dental pulp stem cells ameliorate D-galactose-induced cardiac ageing in rats.
- Authors
El-Akabawy, Gehan; El-Kersh, Sherif Othman Fathy; El-Kersh, Ahmed Othman Fathy Othman; Amin, Shaimaa Nasr; Rashed, Laila Ahmed; Abdel Latif, Noha; Elshamey, Ahmed; Abdallah, Mohamed Abdallah Abd El Megied; Saleh, Ibrahim G.; Hein, Zaw Myo; El-Serafi, Ibrahim; Eid, Nabil
- Abstract
Background: Ageing is a key risk factor for cardiovascular disease and is linked to several alterations in cardiac structure and function, including left ventricular hypertrophy and increased cardiomyocyte volume, as well as a decline in the number of cardiomyocytes and ventricular dysfunction, emphasizing the pathological impacts of cardiomyocyte ageing. Dental pulp stem cells (DPSCs) are promising as a cellular therapeutic source due to their minimally invasive surgical approach and remarkable proliferative ability. Aim: This study is the first to investigate the outcomes of the systemic transplantation of DPSCs in a D-galactose (D-gal)-induced rat model of cardiac ageing. Methods. Thirty 9-week-old Sprague-Dawley male rats were randomly assigned into three groups: control, ageing (D-gal), and transplanted groups (D-gal + DPSCs). D-gal (300 mg/kg/day) was administered intraperitoneally daily for 8 weeks. The rats in the transplantation group were intravenously injected with DPSCs at a dose of 1 × 106 once every 2 weeks. Results: The transplanted cells migrated to the heart, differentiated into cardiomyocytes, improved cardiac function, upregulated Sirt1 expression, exerted antioxidative effects, modulated connexin-43 expression, attenuated cardiac histopathological alterations, and had anti-senescent and anti-apoptotic effects. Conclusion: Our results reveal the beneficial effects of DPSC transplantation in a cardiac ageing rat model, suggesting their potential as a viable cell therapy for ageing hearts.
- Subjects
DENTAL pulp; GALACTOSE; STEM cells; ANIMAL models for aging; LEFT ventricular hypertrophy; DISEASE risk factors
- Publication
PeerJ, 2024, p1
- ISSN
2167-8359
- Publication type
Article
- DOI
10.7717/peerj.17299