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- Title
The mechanisms underlying MMR deficiency in immunodeficiency-related non-Hodgkin lymphomas are different from those in other sporadic microsatellite instable neoplasms.
- Authors
Borie, Claire; Colas, Chrystelle; Dartigues, Peggy; Lazure, Thierry; Rince, Patricia; Buhard, Olivier; Folliot, Patrick; Chalastanis, Alexandra; Muleris, Martine; Hamelin, Richard; Mercier, Dominique; Oliveira, Carla; Seruca, Raquel; Chadburn, Amy; Leblond, Véronique; Barete, Stéphane; Gaïdano, Gianluca; Martin, Antoine; Gaulard, Philippe; Fléjou1, Jean-François
- Abstract
The spectrum of tumors showing microsatellite instability (MSI) has recently been enlarged to sporadic neoplasms whose incidence is favored in the context of chronic immunosuppression. We investigated the biological, therapeutic and clinical features associated with MSI in immunodeficiency-related non-Hodgkin lymphomas (ID-RL). MSI screening was performed in 275 ID-RL. MSI ID-RL were further analyzed for MMR gene expression and for BRAF/KRAS mutations since these genes are frequently altered in MSI cancers. We also assessed the expression of O
- Publication
International Journal of Cancer, 2009, Vol 125, Issue 10, p2360
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.24681