We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Glutamate and GABA-Metabolizing Enzymes in Post-mortem Cerebellum in Alzheimer's Disease: Phosphate-Activated Glutaminase and Glutamic Acid Decarboxylase.
- Authors
Burbaeva, G.; Boksha, I.; Tereshkina, E.; Savushkina, O.; Prokhorova, T.; Vorobyeva, E.
- Abstract
Enzymes of glutamate and GABA metabolism in postmortem cerebellum from patients with Alzheimer's disease (AD) have not been comprehensively studied. The present work reports results of original comparative study on levels of phosphate-activated glutaminase (PAG) and glutamic acid decarboxylase isoenzymes (GAD65/67) in autopsied cerebellum samples from AD patients and matched controls (13 cases in each group) as well as summarizes published evidence for altered levels of PAG and GAD65/67 in AD brain. Altered (decreased) levels of these enzymes and changes in links between amounts of these enzymes and other glutamate-metabolizing enzymes (such as glutamate dehydrogenase and glutamine synthetase-like protein) in AD cerebella suggest significantly impaired glutamate and GABA metabolism in this brain region, which was previously regarded as not substantially involved in AD pathogenesis.
- Subjects
GLUTAMATE decarboxylase; ALZHEIMER'S disease; GABA; ENZYME activation; CEREBELLUM development; GLUTAMINASES
- Publication
Cerebellum, 2014, Vol 13, Issue 5, p607
- ISSN
1473-4222
- Publication type
Article
- DOI
10.1007/s12311-014-0573-4