We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
High-Capacity Calcium Carbonate Particles As pH-Sensitive Containers for Doxorubicin.
- Authors
Pallaeva, T. N.; Mikheev, A. V.; Khmelenin, D. N.; Eurov, D. A.; Kurdyukov, D. A.; Popova, V. K.; Dmitrienko, E. V.; Trushina, D. B.
- Abstract
Nanostructured submicron calcium carbonate particles with sizes of 500 ± 90 and 172 ± 75 nm have been synthesized by mass crystallization in aqueous solutions with addition of glycerol, as well as a mixture of polyethylene glycol, polysorbate, and a cellular medium. CaCO3:Si:Fe nanoparticles 65 ± 15 nm in size have been obtained by template synthesis in pores of silica particles. The crystal structure and polymorphism of these particles are studied, and the influence of the size and structure of particles on the efficiency of their loading with a chemotherapy agent, as well as its release under model conditions at different рН, is determined.
- Subjects
DOXORUBICIN; CALCIUM carbonate; POLYETHYLENE glycol; SILICA nanoparticles; AQUEOUS solutions; CRYSTAL structure; CONTAINERS
- Publication
Crystallography Reports, 2023, Vol 68, Issue 2, p309
- ISSN
1063-7745
- Publication type
Article
- DOI
10.1134/S1063774523020128