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- Title
Sotalol, unlike the other beta‐blockers, increases the QT<sub>c</sub> interval and risk of torsades de pointes ventricular tachycardia in severe poisonings.
- Authors
Neuvonen, Pertti J.; Elonen, Erkki
- Abstract
In a later report, all the six sotalol intoxication patients had developed QTc interval, up to 172% ± 8% of normal.[4] The QT intervals were at their longest 4-15 hours after sotalol ingestion. The correlation between the serum sotalol concentration and QTc prolongation suggests that the QTc interval could be used as an index of the sotalol poisoning severity. Besides hypotension and bradycardia, which are usual in all beta-blocker poisonings, prolonged QTc and malignant tachyarrhythmias are common after high sotalol doses and may need careful follow-up and specific treatment, at least up to 24 hours after ingestion.[[4], [8]].
- Subjects
VENTRICULAR tachycardia; POISONING; ADRENERGIC beta blockers; ACTIVATED carbon; BLOOD pressure; VENTRICULAR arrhythmia
- Publication
Basic & Clinical Pharmacology & Toxicology, 2019, Vol 125, Issue 6, p487
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/bcpt.13333