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- Title
Plasma Levels of 25-Hydroxyvitamin D<sub>3</sub> and In Vivo Markers of Cytochrome P450 3 A Activity in Swedes and Koreans: Effects of a Genetic Polymorphism and Oral Contraceptives.
- Authors
Nylén, Hanna; Björkhem‐Bergman, Linda; Ekström, Lena; Roh, Hyung‐Keun; Bertilsson, Leif; Eliasson, Erik; Lindh, Jonatan D.; Diczfalusy, Ulf
- Abstract
In vitro studies have shown that vitamin D may induce several cytochrome P450 ( CYP) enzymes in general and CYP3 A4 in particular. The primary aim of this study was to investigate the relationship between plasma levels of 25-hydroxyvitamin D3 and suggested in vivo markers of CYP3 A activity in healthy volunteers from Sweden and Korea. Plasma concentrations of 25-hydroxyvitamin D3 were analysed in samples from three previously performed studies, and the correlation between these levels and suggested in vivo markers of CYP3 A activity was investigated by means of nonparametric correlation. In addition, we studied the modulating effects of three vitamin D receptor promoter polymorphisms on the association between 25-hydroxyvitamin D3 and CYP3 A enzyme activity in Swedish subjects. The plasma levels of 25-hydroxyvitamin D3 were not significantly associated with CYP3 A phenotypes in any of the three studies, but after accounting for the vitamin D receptor polymorphism rs4516035, there was a significant positive association between 25-hydroxyvitamin D3 and CYP3 A activity ( p = 0.004). Swedes (n = 65) had significantly higher 25-hydroxyvitamin D3 levels than Koreans (n = 67), 75 nM compared with 31 nM ( p < 0.001). Swedish women taking oral contraceptives ( OC) (n = 19) had somewhat higher plasma levels of 25-hydroxyvitamin D3 compared with Swedish women not taking oral contraceptives (n = 21), 89 and 72 nM, respectively ( p = 0.02). In conclusion, our results suggest that the overall influence on the CYP3 A activity by 25-hydroxyvitamin D3 is of marginal importance.
- Subjects
SWEDEN; KOREA; CYTOCHROME P-450; CALCITRIOL; GENETIC polymorphisms; PHYSIOLOGICAL effects of oral contraceptives; IN vitro studies
- Publication
Basic & Clinical Pharmacology & Toxicology, 2014, Vol 115, Issue 4, p366
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/bcpt.12230