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- Title
HERV-K Modulates the Immune Response in ALS Patients.
- Authors
Arru, Giannina; Galleri, Grazia; Deiana, Giovanni A.; Zarbo, Ignazio R.; Sechi, Elia; Bo, Marco; Cadoni, Maria Piera L.; Corda, Davide G.; Frau, Claudia; Simula, Elena R.; Manca, Maria Antonietta; Galistu, Franca; Solla, Paolo; Manetti, Roberto; Sechi, Gian Pietro; Sechi, Leonardo A.
- Abstract
Human endogenous retrovirus (HERV)-K env-su glycoprotein has been documented in amyotrophic lateral sclerosis (ALS), where HERV-K env-su 19–37 antibody levels significantly correlated with clinical measures of disease severity. Herein, we investigated further the humoral and cell-mediated immune response against specific antigenic peptides derived from HERV-K in ALS. HERV-K env glycoprotein expression on peripheral blood mononuclear cells (PBMCs) membrane and cytokines and chemokines after stimulation with HERV-K env 19–37 and HERV-K env 109–126 were quantified in patients and healthy controls (HCs). HERV-K env glycoprotein was more expressed in B cells and NK cells of ALS patients compared to HCs, whereas HERV-K env transcripts were similar in ALS and HCs. In ALS patients, specific stimulation with HERV-K env 109–126 peptide showed a higher expression of IL-6 by CD19/B cells. Both peptides, however, were able to induce a great production of IFN-γ by stimulation CD19/B cells, and yielded a higher expression of MIP-1α and a lower expression of MCP-1. HERV-K env 19–37 peptide induced a great production of TNF-α in CD8/T cells. In conclusion, we observed the ability of HERV-K to modulate the immune system, generating mediators mainly involved in proinflammatory response.
- Subjects
MONONUCLEAR leukocytes; IMMUNE response; AMYOTROPHIC lateral sclerosis; KILLER cells; IMMUNE system
- Publication
Microorganisms, 2021, Vol 9, Issue 8, p1784
- ISSN
2076-2607
- Publication type
Article
- DOI
10.3390/microorganisms9081784