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- Title
Synthesis, Characterisation and Biological Activity of Schiff Base and its Cu(II), Pd(II), Pt(II) Complexes Derived from Tyrosine and Aromatic Aldehyde.
- Authors
Anjum, Rukhsana; Khan, Bushra; Javed, Muhammad
- Abstract
Schiff base derived from the condensation of tyrosine and the salicylaldehyde has been synthesised and its Cu(II), Pd(II) and Pt(II) complexes have been prepared. The prepared Schiff base and its complexes were analysed and characterised by using different instrumental techniques, such as elemental analysis, FTIR, UV-Vis, 1H NMR, thermal analysis and XRD. The analytical data revealed that the ligand L-1 can coordinate in tridentate manner via the phenolate-O, azomethine-N and tyrosine O-atoms, resulting in the formation of 1:1 [metal: ligand] complexes. Thermal analysis revealed the presence of water molecules in the complexes. In vitro antibacterial activity of the complexes was evaluated against different bacterial strains e.g., Pseudomonas aeruginosa and Bacillus subtilis by the well-diffusion method. The data showed that transition metal complexes have significant improved antibacterial activity than parent drug.
- Subjects
SCHIFF base derivatives; TYROSINE; COPPER compounds synthesis; PALLADIUM compound synthesis; PLATINUM compound synthesis; AROMATIC aldehydes; ANTIBACTERIAL agents; TRANSITION metal complexes
- Publication
Pakistan Journal of Scientific & Industrial Research Series A: Physical Sciences, 2018, Vol 61, Issue 1, p1
- ISSN
2221-6413
- Publication type
Article
- DOI
10.52763/pjsir.phys.sci.61.1.2018.1.7