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- Title
Aortic Distensibility and Aortic Intima-Media Thickness in Patients without Clinical Manifestation of Atherosclerotic Cardiovascular Disease.
- Authors
Elbasan, Zafer; Şahin, Durmuş Yıldıray; Gür, Mustafa; Kalkan, Gülhan Yüksel; Yıldız, Ali; Kaya, Zekeriya; Kıvrak, Ali; Gözübüyük, Gökhan; Özdoğru, Ibrahim; Çaylı, Murat
- Abstract
Background: There is growing evidence that aortic distensibility ( AD) is a subclinical marker of early atherosclerosis. Aortic intima-media thickness ( IMT) was an earlier marker than carotid IMT of preclinical atherosclerosis. In this study, we aimed to assess the relationship between thoracic aortic IMT and AD. Methods: We studied 192 patients (mean age: 45.5 ± 8.4 years) who underwent transesophageal echocardiography ( TEE) for various indications. Four different grades were determined according to IMT of thoracic aorta (Grade 1 < 1 mm; 1 mm ≤ Grade 2 < 3 mm; 3 mm ≤ Grade 3 < 5 mm; 5 mm ≤ Grade 4). AD was calculated from the echocardiographically derived ascending aorta diameters and hemodynamic pressure measurements in all patients. High sensitive C-reactive protein (hs CRP) and other biochemical markers were measured using an automated chemistry analyzer. Results: TEE evaluation characterized thoracic aortic intimal morphology as grade 1 in 71 patients (37%), grade 2 in 57 patients (29.7%), grade 3 in 34 patients (17.7%), and grade 4 in 30 (15.6%) patients. The lowest AD level was observed in grade 4 group compared with grade 1 and grade 2 groups (P < 0.001, P = 0.009, respectively). AD level of grade 3 group was lower than grade 1 and grade 2 group (P < 0.001, P = 0.021, respectively). In multiple linear regression analysis, AD was independently associated with age (β = −0.138, P = 0.029), hs CRP (β = −0.209, P = 0.001), and aortic IMT (β = −0.432, P < 0.001). Conclusion: AD is independently associated with age, thoracic aortic IMT, and hs CRP. Impaired elasticity index of the aorta might be an independent predictor for the severity of thoracic atherosclerosis.
- Subjects
ATHEROSCLEROSIS risk factors; ECHOCARDIOGRAPHY; ANALYSIS of variance; AORTA; BIOMARKERS; BLOOD pressure; CARDIAC output; CHI-squared test; STATISTICAL correlation; HEART beat; STATISTICS; DATA analysis; MULTIPLE regression analysis; DATA analysis software; DESCRIPTIVE statistics
- Publication
Echocardiography, 2013, Vol 30, Issue 4, p407
- ISSN
0742-2822
- Publication type
Article
- DOI
10.1111/echo.12066