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- Title
Nomogram Using Prostate Health Index for Predicting Prostate Cancer in the Gray Zone: Prospective, Multicenter Stud.
- Authors
Jae Hoon Chung; Jeong Hyun Kim; Sang Wook Lee; Hongzoo Park; Geehyun Song; Wan Song; Minyong Kang; Hyun Hwan Sung; Hwang Gyun Jeon; Byong Chang Jeong; Seong IL Seo; Hyun Moo Lee; Seong Soo Jeon
- Abstract
Purpose: To create a nomogram that can predict the probability of prostate cancer using prostate health index (PHI) and clinical parameters of patients. And the optimal cut-off value of PHI for prostate cancer was also assessed. Materials and Methods: A prospective, multi-center study was conducted. PHI was evaluated prior to biopsy in patients requiring prostate biopsy due to high prostate-specific antigen (PSA). Among screened 1,010 patients, 626 patients with clinically suspected prostate cancer with aged 40 to 85 years, and with PSA levels ranging from 2.5 to 10 ng/mL were analyzed. Results: Among 626 patients, 38.82% (243/626) and 22.52% (141/626) were diagnosed with prostate cancer and clinically significant prostate cancer, respectively. In the PSA 2.5 to 4 ng/mL group, the areas under the curve (AUCs) of the nomograms for overall prostate cancer and clinically significant prostate cancer were 0.796 (0.727–0.866; p<0.001), and 0.697 (0.598– 0.795; p=0.001), respectively. In the PSA 4 to 10 ng/mL group, the AUCs of nomograms for overall prostate cancer and clinically significant prostate cancer were 0.812 (0.783–0.842; p<0.001), and 0.839 (0.810–0.869; p<0.001), respectively. Conclusions: Even though external validations are necessary, a nomogram using PHI might improve the prediction of prostate cancer, reducing the need for prostate biopsies
- Subjects
PROSTATE cancer; NOMOGRAMS in electronics; PROSTATE biopsy; PROSTATE-specific antigen; CANCER patient care
- Publication
World Journal of Men's Health, 2024, Vol 42, Issue 1, p168
- ISSN
2287-4208
- Publication type
Article
- DOI
10.5534/wjmh.220223