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- Title
Reliability of real‐time continuous glucose monitoring in infants.
- Authors
Tomotaki, Seiichi; Toyoshima, Katsuaki; Shimokaze, Tomoyuki; Kawai, Masahiko
- Abstract
Background: Neonatal hypoglycemia is a common and treatable risk factor for neurological impairment. Real‐time continuous glucose monitoring (RT‐CGM) can show glucose concentration in real time. Using an RT‐CGM alarm, physicians can be alerted and intervene in hypoglycemia. No reports, however, have evaluated the reliability of RT‐CGM at low glucose levels in infants. This study therefore investigated the difference between blood glucose (BG) and RT‐CGM sensor data at low glucose levels and assessed the optimum method of using a hypoglycemic alarm in infants. Methods: We enrolled infants whose glycemic management was difficult. We calculated the mean absolute difference (MAD) and mean absolute relative difference (MARD) between BG and RT‐CGM sensor data. We compared the MAD and MARD between the low BG fluctuation and high BG fluctuation groups. Results: We used RT‐CGM for 12 patients (29 times) and investigated 448 pairs of BG and RT‐CGM sensor data. The MAD between these pairs was 9.3 ± 8.9 mg/dL, and the MARD was 11.5%. The MAD at low glucose was 7.7 ± 6.0 mg/dL, and the MARD was 16.2%. The MAD and MARD were 6.8 ± 5.4 mg/dL and 7.8% in the low fluctuation group and 10.1 ± 9.5 mg/dL and 12.7% in the high fluctuation group, respectively. Conclusions: The difference between BG and RT‐CGM sensor data changes with the degree of fluctuation in BG. When physicians set the hypoglycemic alarm, consideration of this difference and a change in the alarm setting according to the degree of fluctuation in BG may be useful.
- Subjects
BLOOD sugar monitoring; HYPOGLYCEMIA in children; MONITOR alarms (Medicine); MEDICAL equipment reliability; DESCRIPTIVE statistics; GLYCEMIC control; CHILDREN
- Publication
Pediatrics International, 2019, Vol 61, Issue 10, p1001
- ISSN
1328-8067
- Publication type
Article
- DOI
10.1111/ped.13961