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- Title
European guidelines for diagnosis and treatment of adenovirus infection in leukemia and stem cell transplantation: summary of ECIL-4 (2011).
- Authors
Matthes-Martin, S.; Feuchtinger, T.; Shaw, P.J.; Engelhard, D.; Hirsch, H.H.; Cordonnier, C.; Ljungman, P.
- Abstract
Human adenovirus ( HAdV) infections are increasingly recognized as important pathogens in immunocompromised hosts, especially in patients with severely suppressed T-cell function. The 4th European Conference of Infections in Leukemia ( ECIL-4) has developed evidence-based guidelines for diagnosis and management of HAdV infections. The risk for HAdV-associated disease is increased in children, and risk factors for HAdV disease are T-cell depletion, unrelated and cord blood hematopoietic stem cell transplantation, graft-versus-host disease grades III-IV, and lymphopenia. The recommended technique for monitoring of high-risk patients is quantitative polymerase chain reaction. Cidofovir is the most used antiviral therapy, although no controlled study has been performed. HAdV-specific T-cell therapy is in development.
- Subjects
ADENOVIRUS diseases; LEUKEMIA risk factors; STEM cell transplantation; GUIDELINES; HUMAN adenoviruses; IMMUNOCOMPROMISED patients; THERAPEUTICS
- Publication
Transplant Infectious Disease, 2012, Vol 14, Issue 6, p555
- ISSN
1398-2273
- Publication type
Article
- DOI
10.1111/tid.12022