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- Title
Cardiovascular health and risk of hospitalization with COVID-19: A Mendelian Randomization study.
- Authors
Cecelja, Marina; Lewis, Cathryn M.; Shah, Ajay M.; Chowienczyk, Phil
- Abstract
Background: Susceptibility to and severity of COVID-19 is associated with risk factors for and presence of cardiovascular disease. Methods: We performed a 2-sample Mendelian randomization to determine whether blood pressure (BP), body mass index (BMI), presence of type 2 diabetes (T2DM) and coronary artery disease (CAD) are causally related to presentation with severe COVID-19. Variant-exposure instrumental variable associations were determined from most recently published genome-wide association and meta-analysis studies (GWAS) with publicly available summary-level GWAS data. Variant-outcome associations were obtained from a recent GWAS meta-analysis of laboratory confirmed diagnosis of COVID-19 with severity determined according to need for hospitalization/death. We also examined reverse causality using exposure as diagnosis of severe COVID-19 causing cardiovascular disease. Results: We found no evidence for a causal association of cardiovascular risk factors/disease with severe COVID-19 (compared to population controls), nor evidence of reverse causality. Causal odds ratios (OR, by inverse variance weighted regression) for BP (OR for COVID-19 diagnosis 1.00 [95% confidence interval (CI): 0.99–1.01, P = 0.604] per genetically predicted increase in BP) and T2DM (OR for COVID-19 diagnosis to that of genetically predicted T2DM 1.02 [95% CI: 0.9–1.05, P = 0.927], in particular, were close to unity with relatively narrow confidence intervals. Conclusion: The association between cardiovascular risk factors/disease with that of hospitalization with COVID-19 reported in observational studies could be due to residual confounding by socioeconomic factors and /or those that influence the indication for hospital admission.
- Subjects
COVID-19; CARDIOVASCULAR diseases risk factors; GENOME-wide association studies; CARDIOVASCULAR diseases; CORONARY artery disease; TYPE 2 diabetes
- Publication
JRSM Cardiovascular Disease, 2021, p1
- ISSN
2048-0040
- Publication type
Article
- DOI
10.1177/20480040211059374