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- Title
Cyclodextrins as Anti-inflammatory Agents: Basis, Drugs and Perspectives.
- Authors
Lucia Appleton, Silvia; Navarro-Orcajada, Silvia; Martínez-Navarro, Francisco Juan; Caldera, Fabrizio; López-Nicolás, José Manuel; Trotta, Francesco; Matencio, Adrián
- Abstract
Inflammation is a biological response of the immune system to harmful stimuli. Importantly, inflammation is also a hallmark of several human diseases such as cancer or diabetes. Novel drugs to treat this response are constantly researched, but the formulation is usually forgotten. Cyclodextrins (CDs) are a well-known excipient for complexing and drug delivery. Anti-inflammatory drugs and bioactive compounds with similar activities have been favored from these CD processes. CDs also illustrate anti-inflammatory activity per se. This review tried to describe the capacities of CDs in this field, and is divided into two parts: Firstly, a short description of the inflammation disease (causes, symptoms, treatment) is explained; secondly, the effects of different CDs alone or forming inclusion complexes with drugs or bioactive compounds are discussed.
- Subjects
ANTI-inflammatory agents; CYCLODEXTRINS; DOSAGE forms of drugs; BIOACTIVE compounds; DRUGS; INCLUSION compounds; DIABETES
- Publication
Biomolecules (2218-273X), 2021, Vol 11, Issue 9, p1384
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom11091384