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- Title
Effect of Helicobacter pylori eradication on hyperplastic gastric polyps: A systematic review and meta‐analysis.
- Authors
Ouyang, Yaobin; Zhang, Wenjing; Huang, Yancheng; Wang, Yao; Shao, Qing; Wu, Xidong; Lu, Nonghua; Xie, Chuan
- Abstract
Background: There is increasing evidence that the eradication of Helicobacter pylori leads to the regression of gastric hyperplastic polyps (GHPs). We performed a systematic review with a meta‐analysis of randomized controlled trials and observational studies that assessed the effects of eradication. Materials and Methods: We searched the PubMed, Embase, and Cochrane Central Register of Controlled Trials databases for relevant studies with a combination of the terms "Helicobacter pylori" and "polyps." The risk ratio was used to compare the effect of H. pylori eradication/treatment on GHP. We also calculated the pooled disappearance rate of GHP in the H. pylori eradication/treatment group and persistent infection group. Results: We analyzed data from 6 studies, including 3 RCTs. A total of 58/394 patients were included in the H. pylori treatment/successful eradication group, and 57/302 patients were included in the H. pylori untreated/persistent infection group. The pooled rate of GHP elimination after H. pylori treatment/successful eradication was 59% (95% CI, 43%‐75%)/79% (95% CI, 72%‐86%). H. pylori treatment/successful eradication significantly increased the GHP elimination rate [ITT: (pooled rate: 58% vs. 0%, RR =22.24, 95% CI, 4.51– 109.78, p = 0.0001), PP: (pooled rate: 65% vs. 0%, RR =22.25, 95% CI, 4.52– 109.37, p = 0.0001)/(pooled rate: 79% vs. 9%, RR =26.87, 95% CI, 1.34–540.5, p = 0.03)]. Conclusions: Our meta‐analysis showed that after the eradication of H. pylori, most GHPs are eliminated. Moreover, the treatment/successful eradication of H. pylori increased the GHP elimination rate by more than 20 times that in the control group.
- Subjects
HELICOBACTER pylori; POLYPS; RANDOMIZED controlled trials
- Publication
Helicobacter, 2021, Vol 26, Issue 5, p1
- ISSN
1083-4389
- Publication type
Article
- DOI
10.1111/hel.12838