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- Title
Sex differences between Helicobacter pylori infection and cholesterol levels in an adult health checkup program.
- Authors
Seo, Kwang Il; Heo, Jae Joon; Kim, Sung Eun; Park, Seun Ja; Park, Moo In; Moon, Won; Kim, Jae Hyun; Jung, Kyoungwon; Cho, Dae Hyeon
- Abstract
Background: Helicobacter pylori (H pylori) infection is suggested to be a risk factor of metabolic syndrome (MS) and lipid abnormalities. The aim of this study was to investigate the influence of H pylori infection on MS and lipid abnormalities according to sex differences. Materials and Methods: We analyzed a total of 4551 adults who received health checkups from January 2016 to May 2017. We enrolled participants who did not have a history of hypertension, diabetes, hyperlipidemia, or cancer among those who underwent endoscopy with a rapid urease test. Results: We included a total of 1065 participants, and 663 patients (62.3%) were H pylori‐positive. The H pylori infection rate was 59.3% (426/719) in males and 68.5% (237/346) in females. The mean level of total cholesterol (P =.003), low‐density lipoprotein (LDL) cholesterol (P =.046), and triglycerides (P =.029) were statistically higher in H pylori‐infected males. The mean level of high‐density lipoprotein (HDL) cholesterol was statistically lower in H pylori‐infected females (P =.032). Multivariate analysis showed that total cholesterol in males (odds ratio [OR], 1.007; 95% confidence interval [CI], 1.002‐1.011) and HDL cholesterol in females (OR, 0.983; 95% CI, 0.968‐0.998) were associated with active H pylori infection. The prevalence of MS was higher in both male and female H pylori‐infected groups; however, there was no statistical significance. Conclusions: H pylori infection is significantly related to increased total cholesterol in males and to decreased HDL cholesterol in females, which suggests that H pylori could affect lipid profiles and may be different by sex.
- Subjects
HELICOBACTER pylori infections; CHOLESTEROL; HEALTH programs; HIGH density lipoproteins; HELICOBACTER pylori
- Publication
Helicobacter, 2020, Vol 25, Issue 4, p1
- ISSN
1083-4389
- Publication type
Article
- DOI
10.1111/hel.12704