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- Title
Deletions of chromosome 13q in monoclonal gammopathy of undetermined significance.
- Authors
Königsberg, R; Ackermann, J; Kaufmann, H; Zojer, N; Urbauer, E; Krömer, E; Jäger, U; Gisslinger, H; Schreiber, S; Heinz, R; Ludwig, H; Huber, H; Drach, J
- Abstract
Since deletion of chromosome 13q is a clinically relevant feature in multiple myeloma (MM), we analyzed bone marrow plasma cells from 29 patients with monoclonal gammopathy of undetermined significance (MGUS) to investigate the chromosome 13 status in MGUS. Studies were performed by interphase fluorescence in situ hybridization (FISH) with a panel of 13q14-specific probes (RB1, D13S319, D13S25, D13S31). Plasma cells with a deletion of at least one of the 13q14 loci were detected in 13 patients (44.8%) with MGUS. In five patients (17.2%), deletions of all four 13q14-specific probes were observed, and the additional deletion of a 13q telomeric region (D13S327) suggested loss of the entire 13q arm or monosomy 13. Loss of 13q14 was observed to be monoallelic and to occur in 11.0 to 35.0% of plasma cells (cut-off levels for a deletion <10% with all probes). Nine of 17 patients (52.9%) with MM progressing from a pre-existing MGUS had evidence for a deletion of 13q14 as determined by FISH with the RB1 probe. These results suggest that deletion of 13q14 is an early event in the development of monoclonal gammopathies, but its role for the eventual progression to MM remains to be determined prospectively.
- Subjects
MONOCLONAL gammopathies; FLUORESCENCE in situ hybridization; IMMUNOGLOBULIN analysis; B cells; CELL physiology; CHROMOSOME abnormalities; CHROMOSOMES; COMPARATIVE studies; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; MULTIPLE myeloma; GENETIC mutation; PARAPROTEINEMIA; RESEARCH; EVALUATION research; DISEASE progression
- Publication
Leukemia (08876924), 2000, Vol 14, Issue 11, p1975
- ISSN
0887-6924
- Publication type
journal article