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- Title
Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights.
- Authors
Alatise, Olusegun Isaac; Knapp, Gregory C.; Sharma, Avinash; Chatila, Walid K.; Arowolo, Olukayode A.; Olasehinde, Olalekan; Famurewa, Olusola C.; Omisore, Adeleye D.; Komolafe, Akinwumi O.; Olaofe, Olaejinrinde O.; Katung, Aba I.; Ibikunle, David E.; Egberongbe, Adedeji A.; Olatoke, Samuel A.; Agodirin, Sulaiman O.; Adesiyun, Olusola A.; Adeyeye, Ademola; Kolawole, Oladapo A.; Olakanmi, Akinwumi O.; Arora, Kanika
- Abstract
Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West Africa is vital to addressing the regions rising burden of disease. Tissue from unselected Nigerian patients was analyzed with a multigene, next-generation sequencing assay. The rate of microsatellite instability is significantly higher among Nigerian CRC patients (28.1%) than patients from The Cancer Genome Atlas (TCGA, 14.2%) and Memorial Sloan Kettering Cancer Center (MSKCC, 8.5%, P < 0.001). In microsatellite-stable cases, tumors from Nigerian patients are less likely to have APC mutations (39.1% vs. 76.0% MSKCC P < 0.001) and WNT pathway alterations (47.8% vs. 81.9% MSKCC, P < 0.001); whereas RAS pathway alteration is more prevalent (76.1% vs. 59.6%, P = 0.03). Nigerian CRC patients are also younger and more likely to present with rectal disease (50.8% vs. 33.7% MSKCC, P < 0.001). The findings suggest a unique biology of CRC in Nigeria, which emphasizes the need for regional data to guide diagnostic and treatment approaches for patients in West Africa. Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West Africa is important for early detection and treatment. Here, the authors use a multigene next-generation sequencing panel to identify genomic differences in Nigerian CRCs compared to those from TCGA and MSKCC cohorts.
- Subjects
WEST Africa; NIGERIA; COLORECTAL cancer; PHENOTYPES; CANCER patients; MEMORIAL Sloan-Kettering Cancer Center; NUCLEOTIDE sequencing; RECTAL diseases; BEACONS; NANOSATELLITES
- Publication
Nature Communications, 2021, Vol 12, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-021-27106-w