We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
EFFECT OF PRUNUS DULCIS ON EPITHELIAL DAMAGE CAUSED BY NONSTEROIDAL ANTI-INFLAMMATORY DRUGS.
- Authors
Abdullah, Muhammad Saad; Hamid, Shabnam; Butt, Shadab Ahmed
- Abstract
Objective: To assess the effects of Prunus dulcis on gastric epithelium affected by nonsteroidal anti-inflammatory drugs. Study Design: Laboratory based experimental study. Place and Duration of Study: Anatomy Department, Army Medical College Rawalpindi, in collaboration with National Institute of Health (NIH), Islamabad, from Jan 2015 to Dec 2015. Methodology: Forty healthy adult male and female (BALB/c strain) mice, 9-11 weeks age, weighting 30-40gm were used in the experiment and were kept in standard conditions in animal house. Animals were divided into four equal groups. Group A served as control, whereas group B, C and D served as experimental groups. Animals in all groups were given standard lab diet for 60 days. In addition to standard lab diet, experimental groups C and D were given almond oil (extracted without peel of almonds) and finely ground almonds (with peel), respectively, via oral gavage once a day for 60 days. At 60th day, 400 mg/kg of ASA solution was given, via oral gavage needle, to induce gastric ulcers in animals of experimental groups B, C and D. Type of epithelium and height of epithelium were assessed under Light Microscope. Results: Height and type of epithelium improved in experimental groups C and D on intergroup comparison. Whereas group D showed improved protection as compared to group C. Conclusion: Prunus dulcis provides protection, to gastric epithelium, against gastric ulcers induced by nonsteroidal anti inflammatory drugs. In addition, finely granular almonds provided better protective outcome in comparison with almond oil.
- Subjects
RAWALPINDI (Pakistan); ISLAMABAD (Pakistan); ALMOND; ANTI-inflammatory agents; MICROSCOPES; LABORATORY animals; ANIMAL housing
- Publication
Pakistan Armed Forces Medical Journal, 2020, Vol 70, Issue 2, p333
- ISSN
0030-9648
- Publication type
Article