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- Title
IL-2Rα mediates temporal regulation of IL-2 signaling and enhances immunotherapy.
- Authors
Su, Ee W.; Moore, Caitlin J.; Suriano, Samantha; Johnson, Christopher Bryce; Songalia, Neizel; Patterson, Alicia; Neitzke, Daniel J.; Andrijauskaite, Kristina; Garrett-Mayer, Elizabeth; Mehrotra, Shikhar; Paulos, Chrystal M.; Doedens, Andrew L.; Goldrath, Ananda W.; Zihai Li; Cole, David J.; Rubinstein, Mark P.
- Abstract
The article discusses a study focusing on the Interleukin-2 receptor alpha (IL-2Rα) and its mediation of temporal regulation of IL-2 signaling. Topics discussed include the enhancement in immunotherapy due to IL-2Rα mediated temporal regulation of IL-2 signaling, the T regulatory cell expansion, and the CD8+ T cell-induced curative responses in lymphoreplete mice.
- Subjects
INTERLEUKIN-2 receptors; IMMUNOTHERAPY; INTERLEUKIN-2; CYTOTOXIC T cells; LYMPHOCYTES
- Publication
Science Translational Medicine, 2015, Vol 7, Issue 311, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aac8155