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- Title
Poly(L-Lactic Acid) Composite with Surface-Modified Magnesium Hydroxide Nanoparticles by Biodegradable Oligomer for Augmented Mechanical and Biological Properties.
- Authors
Baek, Seung-Woon; Song, Duck Hyun; Lee, Ho In; Kim, Da-Seul; Heo, Yun; Kim, Jun Hyuk; Park, Chun Gwon; Han, Dong Keun
- Abstract
Poly(L-lactic acid) (PLLA) has attracted a great deal of attention for its use in biomedical materials such as biodegradable vascular scaffolds due to its high biocompatibility. However, its inherent brittleness and inflammatory responses by acidic by-products of PLLA limit its application in biomedical materials. Magnesium hydroxide (MH) has drawn attention as a potential additive since it has a neutralizing effect. Despite the advantages of MH, the MH can be easily agglomerated, resulting in poor dispersion in the polymer matrix. To overcome this problem, oligo-L-lactide-ε-caprolactone (OLCL) as a flexible character was grafted onto the surface of MH nanoparticles due to its acid-neutralizing effect and was added to the PLLA to obtain PLLA/MH composites. The pH neutralization effect of MH was maintained after surface modification. In an in vitro cell experiment, the PLLA/MH composites including OLCL-grafted MH exhibited lower platelet adhesion, cytotoxicity, and inflammatory responses better than those of the control group. Taken together, these results prove that PLLA/MH composites including OLCL-grafted MH show excellent augmented mechanical and biological properties. This technology can be applied to biomedical materials for vascular devices such as biodegradable vascular scaffolds.
- Subjects
BIODEGRADABLE nanoparticles; MAGNESIUM hydroxide; BIOMEDICAL materials; TISSUE scaffolds; BIODEGRADABLE materials; OLIGOMERS
- Publication
Materials (1996-1944), 2021, Vol 14, Issue 19, p5869
- ISSN
1996-1944
- Publication type
Article
- DOI
10.3390/ma14195869