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- Title
Evaluation of bone health among epileptic patients using biochemical markers and DEXA scan: an Egyptian study.
- Authors
Fahmy, Ebtesam Mohamed; Rashed, Laila Ahmed; Ismail, Rania Shehata; Helmy, Hanan; Mekkawy, Doaa Atef
- Abstract
Background: An association between antiepileptic drugs, low bone mineral density (BMD), fractures, and abnormalities in bone metabolism has been suggested for a longer period, although conclusive evidence has not been reported.Methods: Thirty epileptic patients and 30 matched healthy subjects participated in the study. Measurements of serum levels of calcium, phosphorus, vitamin D, parathormone, and alkaline phosphatase were done for included subjects. Dual-energy X-ray absorptiometry (DEXA) scan was also performed.Results: Serum calcium, phosphorus, and vitamin D were significantly lower, whereas serum parathormone and alkaline phosphatase were significantly higher in epileptic patients compared to control subjects. Bone mineral density (BMD) abnormalities were detected in 22 patients (73.4%). A statistically significant difference in DEXA scan measurements at different regions was detected between epileptic patients and control subjects. Epileptic patients receiving enzyme inducer antiepileptic drugs (AEDs) had significantly lower serum (calcium, phosphorous, and vitamin D) and lower BMD values compared to those receiving enzyme inhibitors. Results of BMD were positively correlated with serum calcium, phosphorous, and vitamin D, while negatively correlated with serum alkaline phosphatase and duration of therapy.Conclusions: Abnormal bone health is common in epileptic patients. These abnormalities may be attributed to prolonged intake of AEDs especially enzyme inducers.
- Subjects
PEOPLE with epilepsy; BIOMARKERS; BONE density; ANTICONVULSANTS; BONE metabolism
- Publication
Egyptian Journal of Neurology, Psychiatry & Neurosurgery, 2018, Vol 54, Issue 1, p1
- ISSN
1110-1083
- Publication type
Article
- DOI
10.1186/s41983-018-0014-2