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- Title
Role of growth factors in wound healing.
- Authors
Riswana, N. Ashika; Don, K. R.
- Abstract
The wound healing process involves a series of cellular and biochemical events that ultimately lead to tissue repair and regeneration. These events include hemostasis, inflammation, proliferation, epithelialization, maturation, and remodeling of the scar tissue. Wound healing is an evolutionarily conserved, complex, multicellular process that, in skin, aims at barrier restoration. This process involves the coordinated efforts of several cell types including keratinocytes, fibroblasts, myofibroblasts, smooth muscle cells, endothelial cells, immune cells, macrophages, and platelets. The migration, infiltration, proliferation, and differentiation of these cells will culminate in an inflammatory response, the formation of new tissue and ultimately wound closure. This complex process is executed and regulated by an equally complex signaling network involving numerous growth factors, cytokines, and chemokines. These include epidermal growth factor, fibroblast growth factor (FGF), insulin-like growth factor, keratinocyte growth factor, platelet-derived growth factor, transforming growth factor (TGF), and vascular endothelial growth factor. TGF-β, IL-1, and TGF-α. This review will focus on the specific roles of these growth factors and cytokines during the wound healing process.
- Subjects
EPIDERMAL growth factor receptors; ENDOTHELIAL cells; NEOVASCULARIZATION; CELL proliferation; VASCULAR endothelial growth factors
- Publication
Drug Invention Today, 2019, Vol 11, Issue 2, p458
- ISSN
0975-7619
- Publication type
Article