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- Title
Anticarcinogenic effect of Ocimum tenuiflorum on oral cancer cell lines.
- Authors
Hinaz, Nashwah; Geetha, R. V.
- Abstract
Introduction: Cancer is defined as the uncontrollable growth of cells that invade and cause damage to surrounding tissue. Oral cancer appears as a growth or sore in the mouth that does not go away. Oral cancer, which includes cancers of the lips, tongue, cheeks, floor of the mouth, and hard and soft palate, can be life threatening if not diagnosed and treated early. Tulsi is well known for its myriad medicinal properties such as antibacterial, antifungal, antipyretic, antioxidant, antiseptic, and anticancer. Materials and Methods: Tulsi oil extract procured from cyrus enterprises. The anticarcinogenic activity was studied by MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) colorimetric assay using 96-well microtiter plate. Results: The in vitro cytotoxicity study of Tulsi extract showed the direct cytotoxic effect on KB cell lines in a concentration-dependent manner and the half maximal inhibitory concentration value was found to be 100 µg/ml. The percentage of cell inhibition was found to be 88.45% at concentration 400 µg/ml, which is considered significant when compared to control tamoxifen which showed 96.35%. Conclusion: Through the research, it can be concluded that tulsi is effective in the treatment of oral cancer as well. Hence, tulsi can be effectively used for the cancer treatments.
- Subjects
BASIL; ANTICARCINOGENIC agents; ORAL cancer; CANCER treatment; CANCER cells; HERBAL medicine
- Publication
Drug Invention Today, 2018, Vol 10, p2917
- ISSN
0975-7619
- Publication type
Article