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- Title
Acquired mechanisms of immune escape in cancer following immunotherapy.
- Authors
Bryan Iorgulescu, J.; Braun, David; Oliveira, Giacomo; Keskin, Derin B.; Wu, Catherine J.
- Abstract
Immunotherapy has revolutionized the management of numerous cancers; however, a substantial proportion that initially respond subsequently acquire means of immune escape and relapse. Analysis of recent clinical trials permits us to preliminarily understand how immunotherapies exert evolutionary pressures: selecting cancer subclones deficient in antigenicity and/or immunogenicity, thereby facilitating immune escape.
- Subjects
CANCER immunotherapy; IMMUNE response; CANCER treatment; CANCER relapse; CLINICAL trials
- Publication
Genome Medicine, 2018, Vol 10, Issue 1, pN.PAG
- ISSN
1756-994X
- Publication type
Article
- DOI
10.1186/s13073-018-0598-2