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- Title
Daily and alternate-day corticosteroid regimens in treatment of giant cell arteritis: comparison in a prospective study.
- Authors
Hunder, Gene G.; Shelps, Sheldon G.; Allen, George L.; Joyce, John W.; Hunder, G G; Sheps, S G; Allen, G L; Joyce, J W
- Abstract
Alternate-day corticosteroid therapy was compared with two daily corticosteroid regimens for the treatment of giant cell arteritis. In a prospective study 60 patients with this disease were randomly assigned to three treatment groups: group A, 15 mg of prednisone every 8 hours; group B, 45 mg of prednisone every morning; and group C, 90 mgof prednisone every other morning. After 1 month of treatment, the arteritis seemed to be completely suppressed in 18 patients in group A and 16 in group B but in only 6 in group C. In the 14 other patients in group C, the continuing symptoms were cyclic and developed during the day steroids were not given. By changing to a daily regimen, the arteritis was controlled in most patients in group C. Adverse reactions to prednisone were noted frequently in groups A and B but rarely in group C.
- Subjects
CORTICOSTEROIDS; DRUG efficacy; GIANT cell arteritis; ARTERITIS; PREDNISONE; THERAPEUTICS; BIOPSY; CLINICAL trials; COMPARATIVE studies; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; RESEARCH; STATISTICS; EVALUATION research; RANDOMIZED controlled trials; TEMPORAL arteries
- Publication
Annals of Internal Medicine, 1975, Vol 82, Issue 5, p613
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-82-5-613