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- Title
Extensive Literature Review of 46,XX Newborns with Congenital Adrenal Hyperplasia and Severe Genital Masculinization: Should They Be Assigned and Reared Male?
- Authors
Mazur, Tom; O’Donnell, Jennifer; Lee, Peter A.
- Abstract
46,XX individuals born with severely masculinized genitals due to congenital adrenal hyperplasia (CAH) who have been assigned male at birth and reared male can successfully establish a male gender identity/role, find employment, marry, function sexually with a female partner, and develop positive mental health status. While there were a few individuals who reportedly did not fare well or who changed gender to female, the majority of those identifying as males appear to have an overall good quality of life. Parental/family support, along with the support of others, appears essential to a positive outcome as a male, or as a female. This paper suggests that serious consideration should be given to male gender assignment and rearing and, in certain situations, is justified. Disorders of sex differentiation teams should inform parents about the option for male assignment and rearing in 46,XX CAH infants with severe genital masculinization, which is a rare condition. To provide this option is concordant with the principles of ethics, transparency and with the Endocrine Society Guidelines and the American Academy of Pediatrics’ policy of fully informed consent.
- Subjects
ADRENOGENITAL syndrome; SEX differentiation disorders; GENDER role; SEXUAL orientation; GENDER identity; MENTAL health; MARRIAGE; HUMAN sexuality; DISEASES in women; GENDER expression; QUALITY of life; FAMILY support; SOCIAL support
- Publication
Journal of Clinical Research in Pediatric Endocrinology, 2024, Vol 16, Issue 2, p123
- ISSN
1308-5727
- Publication type
Article
- DOI
10.4274/jcrpe.galenos.2023.2023-10-17