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- Title
Cigarette smoke is a risk factor for severity and treatment outcome in patients with culture-positive tuberculosis.
- Authors
Hsiao-Chi Chuang; Chien-Ling Su; Hui-Chiao Liu; Po-Hao Feng; Kang-Yun Lee; Kai-Jen Chuang; Chun-Nin Lee; Mauo-Ying Bien; Chuang, Hsiao-Chi; Su, Chien-Ling; Liu, Hui-Chiao; Feng, Po-Hao; Lee, Kang-Yun; Chuang, Kai-Jen; Lee, Chun-Nin; Bien, Mauo-Ying
- Abstract
<bold>Objective: </bold>Smoking has been associated with tuberculosis (TB); however, the effects of smoking on the effectiveness of TB treatment remain unclear.<bold>Materials and Methods: </bold>Data were retrieved from case notes and interviews of subjects registered in the TB-reporting system from 2010 to 2012. Study cases were defined as subjects with TB-positive sputum cultures, whereas the controls were defined as subjects with non-TB-related pulmonary diseases. Statistical analyses included logistic regression and multivariate Cox proportional hazard regression models.<bold>Results: </bold>A total of 245 cases with cultures positive for TB and 114 controls with non-TB-related pulmonary diseases and negative sputum cultures were recruited. Current smokers had the highest failure rate (33%) for TB treatment, and they had the most severe pulmonary lesions based on chest X-ray grading. Current smokers had a 1.36-fold (95% confidence interval 1.03-2.36, P<0.05) higher odds ratio for cultures positive for TB compared with nonsmokers. In subjects with TB-positive cultures, current smoking was associated with an increase in treatment days required for cultures to convert from positive to negative (hazard ratio 1.12, 95% confidence interval 1.03-1.39; P<0.05).<bold>Conclusion: </bold>Longer periods of treatment may be required for TB patients who are current smokers.
- Subjects
PHYSIOLOGICAL effects of tobacco; TUBERCULOSIS patients; TUBERCULOSIS treatment; HEALTH outcome assessment; INFORMATION storage &; retrieval systems; LUNG diseases
- Publication
Therapeutics & Clinical Risk Management, 2015, Vol 11, p1539
- ISSN
1176-6336
- Publication type
journal article
- DOI
10.2147/TCRM.S87218