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- Title
Model‐dependent outcomes: Sex as a biological variable in preclinical mouse models of melanoma.
- Authors
Parkman, Gennie L.; Kircher, David A.; Stehn, Christopher M.; McMahon, Martin; Holmen, Sheri L.
- Abstract
The average age of tumor onset was 90.6 ± 10.7 ( I SEM i ) days for tumor-bearing male mice and 80.7 ± 11.6 ( I SEM i ) days for tumor-bearing female mice ( I p i = .5452, unpaired I t i test) (Figure 1c). The I DBCP i tumors most closely resemble the Cdk4 SP R24 sp I SP C sp ;Hgf SP tg sp i M3 tumors, which showed the highest correlation with the "melanocytic" differentiation signature, and I Hgf SP tg sp i M4 tumors, which showed the highest correlation with the "transitory" gene expression signature (Figure 2). Tumor latency was determined as the number of days between tumor initiation and sacrifice of the animal due to tumor burden or other health concerns. Keywords: melanoma; mouse models; sex as a biological variable EN melanoma mouse models sex as a biological variable 655 658 4 04/19/21 20210501 NES 210501 Dear Editor, Cutaneous melanoma is the most lethal form of skin cancer and is a complex, heterogeneous disease in terms of its etiology, histopathology, and genetics.
- Subjects
SEX (Biology); MICROPHTHALMIA-associated transcription factor; ANIMAL models in research; ANIMAL disease models; MELANOMA
- Publication
Pigment Cell & Melanoma Research, 2021, Vol 34, Issue 3, p655
- ISSN
1755-1471
- Publication type
Article
- DOI
10.1111/pcmr.12940