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- Title
江苏省15家医院极低/超低出生体重儿 抗生素使用现状调查.
- Authors
赵娟娟; 韩树萍; 余章斌; 潘兆军; 周勤; 姜善雨; 万俊; 张琳; 王淮燕; 孟孟; 徐艳; 陈筱青; 薛梅; 杨丽; 吴明赴; 顾瓅; 卢红艳; 乔瑜; 吴新萍; 谷传丽
- Abstract
Objective To investigate the current status of antibiotic use in very low birth weight/extremely low birth weight infants in Jiangsu Province of China, and to provide a clinical basis for the quality and improvement of antibiotic management in the neonatal intensive care unit (NICU). Methods A retrospective analysis was performed on the data on general conditions and antibiotic use in the very low birth weight/extremely low birth weight infants who were admitted to 15 hospitals of Jiangsu Province from January 1, 2019 to December 31, 2020. A questionnaire containing 10 measures to reduce antibiotic use was designed to investigate the implementation of these intervention measures. Results A total of 1 920 very low birth weight/extremely low birth weight infants were enrolled, among whom 1 846 (96.15%) were treated with antibiotic, and the median antibiotic use rate (AUR) was 50/100 patient-days. The AUR ranged from 24/100 to 100/100 patient-days in the 15 hospitals. After adjustment for the confounding factors including gestational age, birth weight, and neonatal critical score, the Poisson regression analysis showed that there was a significant difference in the adjusted AUR (aAUR) among the hospitals (P<0.01). The investigation results showed that among the 10 measures to reduce antibiotic use, 8 measures were implemented in less than 50% of these hospitals, and the number of intervention measures implemented was negatively correlated with aAUR (rs=-0.564, P=0.029). Conclusions There is a high AUR among the very low birth weight/extremely low birth weight infants in the 15 hospitals of Jiangsu Province, with a significant difference among hospitals. The hospitals implementing a relatively few measures to reduce antibiotic use tend to have a high AUR. It is expected to reduce AUR in very low birth weight/extremely low birth weight infants by promoting the quality improvement of antibiotic use management in the NICU.
- Subjects
JIANGSU Sheng (China); VERY low birth weight; WEIGHT in infancy; NEONATAL intensive care units; BIRTH weight; GESTATIONAL age
- Publication
Chinese Journal of Contemporary Pediatrics, 2022, Vol 24, Issue 9, p988
- ISSN
1008-8830
- Publication type
Article
- DOI
10.7499/j.issn.1008-8830.2204165