We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Preterm Birth Therapies to Target Inflammation.
- Authors
Pavlidis, Ioannis; Stock, Sarah J.
- Abstract
Preterm birth (PTB; defined as delivery before 37 weeks of pregnancy) is the leading cause of morbidity and mortality in infants and children aged <5 years, conferring potentially devastating short‐ and long‐term complications. Despite extensive research in the field, there is currently a paucity of medications available for PTB prevention and treatment. Over the past few decades, inflammation in gestational tissues has emerged at the forefront of PTB pathophysiology. Even in the absence of infection, inflammation alone can prematurely activate the main components of parturition resulting in uterine contractions, cervical ripening and dilatation, membrane rupture, and subsequent PTB. Mechanistic studies have identified critical elements of the complex inflammatory molecular pathways involved in PTB. Here, we discuss therapeutic options that target such key mediators with an aim to prevent, postpone, or treat PTB. We provide an overview of more traditional therapies that are currently used or being tested in humans, and we highlight recent advances in preclinical studies introducing novel approaches with therapeutic potential. We conclude that urgent collaborative action is required to address the unmet need of developing effective strategies to tackle the challenge of PTB and its complications.
- Subjects
THERAPEUTICS; PREMATURE infants; INFLAMMATION; DISEASES; CERVIX uteri; CELLULAR signal transduction; OBSTETRICS; TISSUES; INTERPROFESSIONAL relations; LABOR (Obstetrics); CHILD mortality; WOMEN'S health; UTERINE contraction
- Publication
Journal of Clinical Pharmacology, 2022, Vol 62, pS79
- ISSN
0091-2700
- Publication type
Article
- DOI
10.1002/jcph.2107