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- Title
Investigating the association between polymorphism of follicle-stimulating hormone receptor gene and ovarian response in controlled ovarian hyperstimulation.
- Authors
Sheikhha, Mohammad Hasan; Eftekhar, Maryam; Kalantar, Seyed Mehdi
- Abstract
AIM: The aim of the study was to investigate the association between follicle-stimulating hormone receptor (FSHR) gene polymorphism at Position 680 and the outcomes of controlled ovarian hyperstimulation for in vitro fertilization and embryo transfer (IVF-ET) in infertile women. MATERIALS AND METHODS: One hundred and eight patients under 35 years of age who underwent IVF-ET procedures were included in this study. The hormonal profile and treatment of all patients were analyzed and FSHR polymorphism was examined by polymerase chain reaction-restriction fragment length polymorphism. Women from all groups were classified based on polymorphisms at Position 680, occupied either by asparagines (Asn) or serine (Ser) as Asn/Asn, Asn/Ser, and Ser/Ser genotype. RESULT: Our study showed that all patients in the Asn/Asn group were normal responders and in the Asn/Ser group 64.8% were normal responders and 21.1% and 14.1% were poor and hyper responders respectively. In the Ser/Ser group we did not have normal responders and 46.7% of these patients were poor responders and 53.3% were hyper responders. CONCLUSION: FSH receptor polymorphism is correlated with response to ovarian stimulation.
- Subjects
FOLLICLE-stimulating hormone; HORMONE receptors; OVARIAN hyperstimulation syndrome; GENETIC polymorphisms; FERTILIZATION in vitro; EMBRYO transfer; FEMALE infertility
- Publication
Journal of Human Reproductive Sciences, 2011, Vol 4, Issue 2, p86
- ISSN
0974-1208
- Publication type
Article
- DOI
10.4103/0974-1208.86089