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- Title
Vitamin K Antagonist Use and Fracture.
- Authors
Lau, Wallis C. Y.; Man, Kenneth K. C.; Wong, Ian C. K.
- Abstract
We read with interest the article by Fiordellisi and colleagues, who reported findings of a systematic review and meta-analysis on the association between vitamin K antagonist (VKA) use and fracture.[1] The results provide an important contribution to better understand the risk of fractures associated with VKA use, which is still controversial and not well described in clinical practice. One of the key findings of Fiordellisi et al. was that there was no association between a higher risk of fracture and the use of VKA versus non-vitamin K antagonist oral anticoagulant (NOAC). Our findings contradict with Fiordellisi et al. and might raise questions on the validity of their results, and the foundation of the study conclusion regarding whether fracture risk should be considered when choosing an oral anticoagulant.
- Subjects
VITAMIN K; META-analysis; RISK factors of fractures; ANTICOAGULANTS; DRUG side effects
- Publication
JGIM: Journal of General Internal Medicine, 2020, Vol 35, Issue 1, p396
- ISSN
0884-8734
- Publication type
letter
- DOI
10.1007/s11606-019-05185-2