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- Title
Microglial Sirtuin 2 Shapes Long-Term Potentiation in Hippocampal Slices.
- Authors
Sa de Almeida, Joana; Vargas, Mariana; Fonseca-Gomes, João; Tanqueiro, Sara Ramalho; Belo, Rita F.; Miranda-Lourenço, Catarina; Sebastião, Ana M.; Diógenes, Maria José; Pais, Teresa F.
- Abstract
Microglial cells have emerged as crucial players in synaptic plasticity during development and adulthood, and also in neurodegenerative and neuroinflammatory conditions. Here we found that decreased levels of Sirtuin 2 (Sirt2) deacetylase in microglia affects hippocampal synaptic plasticity under inflammatory conditions. The results show that long-term potentiation (LTP) magnitude recorded from hippocampal slices of wild type mice does not differ between those exposed to lipopolysaccharide (LPS), a pro-inflammatory stimulus, or BSA. However, LTP recorded from hippocampal slices of microglial-specific Sirt2 deficient (Sirt2–) mice was significantly impaired by LPS. Importantly, LTP values were restored by memantine, an antagonist of N-methyl-D-aspartate (NMDA) receptors. These results indicate that microglial Sirt2 prevents NMDA-mediated excitotoxicity in hippocampal slices in response to an inflammatory signal such as LPS. Overall, our data suggest a key-protective role for microglial Sirt2 in mnesic deficits associated with neuroinflammation.
- Subjects
LONG-term potentiation; NEUROPLASTICITY; MICROGLIA; INFLAMMATION
- Publication
Frontiers in Neuroscience, 2020, Vol 14, p1
- ISSN
1662-4548
- Publication type
Article
- DOI
10.3389/fnins.2020.00614