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- Title
Thiosemicarbazone and thiazolylhydrazones of 1-indanone: As a new class of nonacidic anti-inflammatory and antiplatelet aggregation agents.
- Authors
Nazim, Urooj; Ahmed, Mansoor; Ali, Basharat; Khan, Khalid Mohammed; Ali, Mohsin; Kobarfard, Farzad; Arshia; Ayatollahi, S. Abdul Majid; Hassan, Amir; Jabeen, Almas; Faheem, Ayesha
- Abstract
This research based on the anti-inflammatory and antiplatelet aggregation properties of some new thiazolyl hydrazone derivatives of 1-indanone. In this regard a thiosemicabazone and twelve thiazolyl derivatives of 1-indanone have been synthesized. Out of these synthetic compounds seven derivatives 1-3, 6, 11-13 exhibited varying degree of anti-inflammatory action with IC50 esteems going from 5.1±1.3 - 78.8±4.6µM/mL. Compound 1 (IC50 =5.1±1.9µM) displayed potent result than standard ibuprofen (IC50 = 11.2±1.9 µM). In antiplatelet aggregation assay, five compounds 1, 5, 6, 8 and 11 were observed to be dynamic with IC50 esteems observed in the range of 38.34-255.7±4.1µM, whereas, aspirin (IC50 = 30.3±2.6 µM) was used as standard. However, compound 11 was found to be good active for both antiinflammatory and antiplatelet aggregation activities (IC50 = 13.9±4.9µg/mL) (IC50 = 38.60±3.1µM), respectively.
- Subjects
THIOSEMICARBAZONES; ASPIRIN; PLATELET aggregation inhibitors; HYDRAZONE derivatives
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2019, Vol 32, Issue 1, p15
- ISSN
1011-601X
- Publication type
Article