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- Title
Plasmid borne BAC-IB17: Localization of a potential antibacterial positive marker (Bac<sup>+</sup>) encoded broad inhibitory spectrum bacteriocin.
- Authors
Ansari, Asma; Siddiqui, Nadir Naveed; Ghani, Maria; Aman, Afsheen; Ul Qader, Shah Ali
- Abstract
Production of antimicrobial compounds is considered as ubiquitous anti-competitor strategy in bacterial ecosystem. Bacteriocins are heterogeneous; highly specific and efficient anti-competitor agents and the gene responsible for the production of bacteriocins mostly exist in an autosomal state and associated with plasmids. BAC-IB17 is a broad spectrum bacteriocin and its production was observed at different stages of the growth cycle from Bacillus subtilis KIBGE-IB17. Growth kinetics of B. subtilis KIBGE-IB17 along with the production of BAC-IB17 showed that it exhibited secondary metabolite kinetics. Plasmid curing technique revealed that the gene responsible for the bacteriocinogenecity in B. subtilis KIBGE-IB17 was located on the plasmid of the bacterium. Overlay method also demonstrated the plasmid-mediated bacteriocinogenesis of the isolated colonies. With the advancement in genomics and proteomics, the plasmid borne BAC-IB17 can play a significant role in the transfer of bacteriocinogenic factor to other incompetent cells and also in the maintenance of plasmid in bacterial population.
- Subjects
BACILLUS subtilis; ANTI-infective agents; BIOMARKERS; PLASMIDS; BACTERIOCINS; DRUGS spectra
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2015, Vol 28, Issue 4, p1331
- ISSN
1011-601X
- Publication type
Article