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- Title
B cells in glomerulonephritis: focus on lupus nephritis.
- Authors
Clatworthy, Menna; Smith, Kenneth
- Abstract
The production of pathogenic antibody has been traditionally viewed as the principle contribution of B cells to the pathogenesis of immune-mediated glomerulonephritis. However, it is increasingly appreciated that B cells play a much broader role in such diseases, functioning as antigen-presenting cells, regulators of T cells, dendritic cells, and macrophages and orchestrators of local lymphatic expansion. In this review, we provide an overview of basic B cell biology and consider the evidence implicating B cells in one of the archetypal immune-mediated glomerulonephritides, lupus nephritis.
- Subjects
B cells; KIDNEY diseases; GLOMERULONEPHRITIS; LUPUS nephritis; AUTOIMMUNITY; SYSTEMIC lupus erythematosus; MACROPHAGES
- Publication
Seminars in Immunopathology, 2007, Vol 29, Issue 4, p337
- ISSN
1863-2297
- Publication type
Article
- DOI
10.1007/s00281-007-0092-1