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- Title
PROPOLİS VE ARI SÜTÜ İÇEREN CİLT KREMİ: ANTİOKSİDAN, ANTİ-HYALÜRONİDAZ VE ANTİMİKROBİYAL AKTİVİTELERİN DEĞERLENDİRMESİ.
- Authors
BOYRACI, Gülsüm Merve; DEĞİRMENCİ, Atiye; YILDIZ, Oktay; ÇELEBİ, Zeynep Berin
- Abstract
Propolis and royal jelly have been used in traditional and modern medical practices since earlier times, owing to their diverse range of biological activities. Recent studies have demonstrated the potential application of these products in the field of skin treatment and care. The purpose of this study is to examine the potential application of propolis and royal jelly in cream formulation and to evaluate the anti-hyaluronidase, antioxidant, and antimicrobial activities of skin cream formulation enriched with bee products. It was also investigated the physical stability of creams at various storage temperatures and durations. The cream formulation maintained a ratio of royal jelly at 0,5% while varying amounts of propolis extract ranging from 0,5% to 1,0% to 1,5% were utilized. The pH values of the creams examined in the study ranged from 5,56 to 6,02, indicating that they were compatible with the pH value of the skin. It was observed that the antioxidant activity values increased statistically as the propolis ratio increased in the cream formulation. As a result of the antihyaluronidase activity analysis of the cream samples, the IC50 values were determined as 0,1667-3,3460 g/mL cream and the sample with 1,5% propolis extract showed the highest activity. The cream samples with propolis and royal jelly exhibited inhibitory activity against Bacillus cereus, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans. The results of accelerated stability testing indicate that the cream formulation exhibits exceptional stability when subjected to various stress situations. This study provides evidence of the feasibility of integrating bee products into cream formulation to produce natural, sustainable, and safe skin care products in the cosmetics industry.
- Subjects
ROYAL jelly
- Publication
Uludag Bee Journal, 2023, Vol 23, Issue 2, p224
- ISSN
1303-0248
- Publication type
Article
- DOI
10.31467/uluaricilik.1355264