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- Title
The Vitamin C:Vitamin K3 System -- Enhancers and Inhibitors of the Anticancer Effect.
- Authors
Lamson, Davis W.; Yu-Huan Gu; Plaza, Steven M.; Brignall, Matthew S.; Brinton, Cathy A.; Sadlon, Angela E.
- Abstract
The oxidizing anticancer system of vitamin C and vitamin K3 (VC:VK3, producing hydrogen peroxide via Superoxide) was combined individually with melatonin, curcumin, quercetin, or cholecalciferol (VD3) to determine interactions. Substrates were LNCaP and PC-3 prostate cancer cell lines. Three of the tested antioxidants displayed differences in cell line cytotoxicity. Melatonin combined with VC:VK3 quenched the oxidizing effect, while VC:VK3 applied 24 hours after melatonin showed no quenching. With increasing curcumin concentrations, an apparent combined effect of VC:VK3 and curcumin occurred in LNCaP cells, but not PC-3 cells. Quercetin alone was cytotoxic on both cell lines, but demonstrated an additional 50-percent cytotoxicity on PC-3 cells when combined with VC:VK3. VD3 was effective against both cell lines, with more effect on PC-3. This effect was negated on LNCaP cells with the addition of VC:VK3. In conclusion, a natural antioxidant can enhance or decrease the cytotoxicity of an oxidizing anticancer system in vitro, but generalizations about antioxidants cannot be made.
- Subjects
THERAPEUTIC use of vitamin C; THERAPEUTIC use of vitamin D; VITAMIN K; ANALYSIS of variance; COMBINATION drug therapy; MELATONIN; PROSTATE tumors; RESEARCH funding; VITAMIN therapy
- Publication
Alternative Medicine Review, 2010, Vol 15, Issue 4, p345
- ISSN
1089-5159
- Publication type
Article