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- Title
Does a four-week delay in the introduction of medication alter the course of functional psychosis?
- Authors
Johnstone, Eve C.; Crow, Timothy J.; Davis, John M.; Owens, David G. C.; Johnstone, E C; Owens, D G; Crow, T J; Davis, J M
- Abstract
This study is an analysis of findings of a follow-up study of 105 patients with functional psychotic illness who had participated in a random and blind 4-week trial of pimozide, lithium, both and placebo. The intention was to examine the question of whether a 4-week delay in initiating antipsychotic treatment has a detrimental effect 2.5 years later. Detailed follow-up measures included need for care over the 2.5 years, treatments required, occupational decline, police contact, substance misuse, psychopathology and cognitive function. There was no evidence at all that those initially randomized to placebo had a poorer outcome in terms of any of these variables. It is concluded that a 4-week delay in initiating active treatment in patients with functional psychosis has no long-term adverse effects.
- Subjects
PSYCHOSES; ANTIPSYCHOTIC agents; THERAPEUTIC use of lithium; DRUG therapy for psychoses; CLINICAL trials; COMPARATIVE studies; EMPLOYMENT; HETEROCYCLIC compounds; LITHIUM; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; PROGNOSIS; PSYCHOLOGICAL tests; RESEARCH; TIME; EVALUATION research; TRANQUILIZING drugs; RANDOMIZED controlled trials; BLIND experiment
- Publication
Journal of Psychopharmacology, 1999, Vol 13, Issue 3, p238
- ISSN
0269-8811
- Publication type
journal article
- DOI
10.1177/026988119901300305