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- Title
ANTIOXIDANT CAPACITY, POLYPHENOL CONTENT AND ANTIPROLIFERATIVE ACTIVITY OF YELLOW, TROPICAL AND ANDEAN BERRIES EXTRACTS OBTAINED FROM MIXTURES OF BLACKBERRY {Rubus glaucus), PASSION FRUIT {Passiflora edulis and Passiflora ligularis), PINEAPPLE (Ananas comosus), GUAVA (Psidium guajava l. Radd) AND PINEAPPLE GUAVA (Acca sellowiana)
- Authors
Peñaloza, J. K.; Canas, J. C.; Rojano, B. A.; Maldonado, M. E.
- Abstract
Fruits are sources of phytochemicals such as phenols and carotenoids with antioxidant and anticancer activities. The objective of this study was to evaluate the antioxidant atid antiproliferative activities of Colombian native fru it extracts (tropical fruit, yellow fru it and Andean beiries) that are rich in bioactive compounds and to correlate antioxidant capacity with phenolic content. Antioxidant activity was measured by FRAP and ORAC. Cytotoxic and antiproliferative effects were analyzed using M T T a n d sulfhorodamine-B respectively on the SW480 cell line. The tropical fru it aqueous extract yielded the highest FRAP and ORAC values and greatest content of total phenolic compounds compared with Andean berries and yellow fruits. Cytotoxic and antiproliferative activities were the lowest in the tropical fru it solution. Correlation analyses for tropical and yellow fruits were similar; both showed positive correlations (p<0.01) between antiproliferative activity, content of bioactive compounds and antioxidant activity, whereas the correlation was negative with respect to cytotoxicity (p < 0.05 for tropical fruits, p < 0.001 for yellow fruits). Correlation between antioxidant activity, bioactive compounds and cytotoxicity was also negative (p < 0.001) in the Andean berries but no correlation was found with antiproliferative effect. Overall, we found that aqueous extracts of Colombian tropical fruits, Andean berries and yellow fruits affect the viability and growth of colon adenocarcinoma SW480 cells and this effect could be partially attributed to their antioxidant activity and/or their phenolic compounds.
- Subjects
ANTIOXIDANTS; PHENOLS; BLACKBERRIES; PASSION fruit; PHYTOCHEMICALS; FRUIT extracts
- Publication
Current Topics in Nutraceutical Research, 2017, Vol 15, Issue 3/4, p163
- ISSN
1540-7535
- Publication type
Article