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- Title
Magnetoliposomes Based on Magnetic/Plasmonic Nanoparticles Loaded with Tricyclic Lactones for Combined Cancer Therapy.
- Authors
Rio, Irina S. R.; Rodrigues, Ana Rita O.; Rodrigues, Juliana M.; Queiroz, Maria-João R. P.; Calhelha, R. C.; Ferreira, Isabel C. F. R.; Almeida, Bernardo G.; Pires, Ana; Pereira, André M.; Araújo, João P.; Castanheira, Elisabete M. S.; Coutinho, Paulo J. G.
- Abstract
Liposome-like nanoarchitectures containing manganese ferrite nanoparticles covered or decorated with gold were developed for application in dual cancer therapy, combining chemotherapy and photothermia. The magnetic/plasmonic nanoparticles were characterized using XRD, UV/Visible absorption, HR-TEM, and SQUID, exhibiting superparamagnetic behavior at room temperature. The average size of the gold-decorated nanoparticles was 26.7 nm for MnFe2O4 with 5–7 nm gold nanospheres. The average size of the core/shell nanoparticles was 28.8 nm for the magnetic core and around 4 nm for the gold shell. Two new potential antitumor fluorescent drugs, tricyclic lactones derivatives of thienopyridine, were loaded in these nanosystems with very high encapsulation efficiencies (higher than 98%). Assays in human tumor cell lines demonstrate that the nanocarriers do not release the antitumor compounds in the absence of irradiation. Moreover, the nanosystems do not cause any effect on the growth of primary (non-tumor) cells (with or without irradiation). The drug-loaded systems containing the core/shell magnetic/plasmonic nanoparticles efficiently inhibit the growth of tumor cells when irradiated with red light, making them suitable for a triggered release promoted by irradiation.
- Subjects
PLASMONICS; CANCER treatment; NANOPARTICLES; MAGNETIC cores; NANOPARTICLE size; NANOCARRIERS; NICKEL ferrite; GOLD nanoparticles
- Publication
Pharmaceutics, 2021, Vol 13, Issue 11, p1905
- ISSN
1999-4923
- Publication type
Article
- DOI
10.3390/pharmaceutics13111905