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- Title
Low CCL17 expression associates with unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma.
- Authors
Ying Xiong; Li Liu; Yu Xia; Jiajun Wang; Wei Xi; Qi Bai; Yang Qu; Jiejie Xu; Jianming Guo; Xiong, Ying; Liu, Li; Xia, Yu; Wang, Jiajun; Xi, Wei; Bai, Qi; Qu, Yang; Xu, Jiejie; Guo, Jianming
- Abstract
<bold>Background: </bold>Chemokine (C-C motif) ligand 17 (CCL17) is a chemokine mainly produced by myeloid dendritic cells. It is a ligand for CC chemokine receptor 4 (CCR4) and CC chemokine receptor 8 (CCR8). The aim of this study was to investigate prognostic values of CCL17 expression in patients with clear cell renal cell carcinoma (ccRCC).<bold>Methods: </bold>The study included 286 patients with ccRCC. CCL17 expression was analyzed by immunohistochemistry on tissue microarrays. Prognostic values of CCL17 expression and patients' clinical outcomes were evaluated.<bold>Results: </bold>Kaplan-Meier method showed that low CCL17 expression was associated with worse patient overall survival (OS) and recurrence-free survival (RFS) (OS, P = 0.002; RFS, P = 0.007). Low CCL17 expression was an adverse independent risk factor for OS and RFS in multivariate analyses (OS, P = 0.006, P = 0.011 for bootstrap; RFS, P = 0.002, P = 0.025 for bootstrap). We constructed two nomograms incorporating parameters derived from multivariate analyses to predict patients' OS and RFS (OS, c-index 0.799; RFS, c-index 0.787) and they performed better than existed integrated models.<bold>Conclusion: </bold>Low CCL17 expression is a potential independent adverse prognostic biomarker for recurrence and survival of patients with ccRCC after nephrectomy. Established nomograms based on this information could help predict ccRCC patients' OS and RFS.
- Subjects
RENAL cell carcinoma; CHEMOKINES; DENDRITIC cells; KAPLAN-Meier estimator; MULTIVARIATE analysis; CYTOKINES; KIDNEYS; KIDNEY tumors; PROGNOSIS; NEPHRECTOMY; SURGERY
- Publication
BMC Cancer, 2017, Vol 17, p1
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-017-3106-y