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- Title
NAFLD Aggravates Septic Shock Due to Inadequate Adrenal Response and 11β-HSDs Dysregulation in Rats.
- Authors
Huang, Hui-Chun; Tsai, Ming-Hung; Lee, Fa-Yauh; Lin, Te-Yueh; Chang, Ching-Chih; Chuang, Chiao-Lin; Hsu, Shao-Jung; Hou, Ming-Chih; Huang, Yi-Hsiang
- Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is linked with metabolic syndrome. Previous studies showed that obesity may disrupt adrenal function and adversely affect its counter-regulations against shock. This study hence evaluated adrenal function abnormalities in NAFLD with shock. Methods: Sprague-Dawley rats were fed with regular chow-diet (control) or high fat diet (HFD, 60% energy derived from fat). Blood tests were performed at the end of the 4th, 6th and 8th week, respectively. Experiments were performed at the end of the 8th week. Results: HFD rats developed NAFLD. HFD rats had 27% and 51% increase in plasma corticosterone at the 6th and 8th week in usual status. However, HFD rats had 5 times more reduction of mean arterial pressure in response to lipopolysaccharide-induced sepsis as compared to control rats. The corticosterone increment ratio was also lower in HFD rats, even after ACTH administration. 11β-HSD system tended to generate more corticosterone in HFD rats under hemodynamic stable status without shock and the trend was lost in HFD rats with septic shock. Conclusion: Rats with NAFLD had profound septic shock due to inadequate corticosterone response. This is, at least partly, due to 11β-HSDs dysregulation in sepsis.
- Subjects
SEPTIC shock; FATTY liver; HIGH-fat diet; LIPOPOLYSACCHARIDES; RATS
- Publication
Pharmaceutics, 2020, Vol 12, Issue 5, p403
- ISSN
1999-4923
- Publication type
Article
- DOI
10.3390/pharmaceutics12050403