We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Azacitidine for the treatment of patients with acute myeloid leukemia.
- Authors
Maurillo, Luca; Venditti, Adriano; Spagnoli, Alessandra; Gaidano, Gianluca; Ferrero, Dario; Oliva, Esther; Lunghi, Monia; D'Arco, Alfonso M.; Levis, Alessandro; Pastore, Domenico; Di Renzo, Nicola; Santagostino, Alberto; Pavone, Vincenzo; Buccisano, Francesco; Musto, Pellegrino
- Abstract
BACKGROUND: The efficacy of azacitidine for the treatment of high-risk myelodysplastic syndromes has prompted the issue of its potential role even in the treatment of acute myeloid leukemia (AML). METHODS: The authors analyzed 82 patients with AML who were diagnosed according to World Health Organization criteria. The median patient age was 72 years (range, 29-87 years), and 27 patients (33%) had secondary AML. Of 62 patients with evaluable cytogenetics, 18 patients (29%) had a poor-risk karyotype, and 44 patients (71%) had an intermediate karyotype. Thirty-five patients (43%) received azacitidine as front-line treatment, and 47 patients (57%) had previously received 1 or more line of chemotherapy. RESULTS: The overall response rate was 32% (26 of 82 patients) and included 12 (15%) complete remissions (CRs), 4 (5%) CRs with incomplete blood count recovery (CRi), and 10 (12%) partial responses (PRs). Responses were observed more frequently among untreated patients compared with pretreated patients; in fact, 17 of 35 untreated patients (48%) responded, including 11 responses (31%) classified as CR/CRi. Conversely, only 9 of 47 pretreated patients (19%) responded, including 5 responses (11%) that were classified as CR/Cri. The response rate was significantly higher for untreated patients ( P = .006) and those who had white blood cell counts <10 × 109/L ( P = .006). For untreated patients who achieved a response, the median overall response duration was 13 months, and the 1-year and 2-years overall survival rates were 58% and 24%, respectively. CONCLUSIONS: The current results indicated that azacitidine promises to be an effective therapy for elderly patients with untreated AML and with white blood cell counts <10 × 109/L. Cancer 2012;. © 2011 American Cancer Society.
- Subjects
CANCER treatment; CANCER patients; ACUTE myeloid leukemia; BONE marrow diseases; BLOOD cell count; AZACITIDINE
- Publication
Cancer (0008543X), 2012, Vol 118, Issue 4, p1014
- ISSN
0008-543X
- Publication type
Article
- DOI
10.1002/cncr.26354