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- Title
The modifying effect of C-reactive protein gene polymorphisms on the association between central obesity and endometrial cancer risk.
- Authors
Wanqing Wen; Qiuyin Cai; Yong-Bing Xiang; Wang-Hong Xu; Zhi Xian Ruan; Jiarong Cheng; Wei Zheng; Xiao-Ou Shu; Wen, Wanqing; Cai, Qiuyin; Xiang, Yong-Bing; Xu, Wang-Hong; Ruan, Zhi Xian; Cheng, Jiarong; Zheng, Wei; Shu, Xiao-Ou
- Abstract
<bold>Background: </bold>Obesity is a major risk factor for endometrial cancer. Obesity, particularly central obesity, is considered as a systemic inflammatory condition and is related strongly to insulin resistance. C-reactive protein (CRP) is the most recognized biologic marker of chronic systematic inflammation, and it is conceivable that the CRP gene may work together with obesity in the development of endometrial cancer.<bold>Methods: </bold>On the basis of a population-based case-control study in a Chinese population, the authors obtained obesity measurements and data on 6 CRP single-nucleotide polymorphisms (SNPs) from 1046 patients with newly diagnosed endometrial cancer (cases) and from 1035 age frequency-matched controls. The association of the CRP SNPs with endometrial cancer risk and their modification on the association between obesity and endometrial cancer risk were evaluated.<bold>Results: </bold>Although CRP SNPs alone were not associated with endometrial cancer, the associations of endometrial cancer with central obesity, measured as the waist-to-hip ratio (WHR) and the waist circumference, seemed to be stronger in women who were homozygous for the major allele of reference SNP (rs)1130864 (cytidine [C]/C) than in women who had the C/thymidine (T) and T/T genotypes (interaction test: P = .013 for WHR; P = .083 for waist circumference). When the women were stratified further by menopausal status, the observed interactions persisted mainly in premenopausal women (interaction test: P < .001 for WHR; P = .002 for waist circumference).<bold>Conclusions: </bold>The current results suggested that, in the Chinese population that was studied, obesity-related insulin resistance and proinflammatory effects may play an important role in endometrial cancer risk, and these effects were modified significantly by the CRP SNP rs1130864.
- Subjects
CHINA; C-reactive protein; GENETIC polymorphisms; OBESITY; ENDOMETRIAL cancer; CANCER risk factors; INSULIN resistance; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESEARCH funding; PERIMENOPAUSE; ENDOMETRIAL tumors; EVALUATION research; BODY mass index; CASE-control method; WAIST-hip ratio; HAPLOTYPES
- Publication
Cancer (0008543X), 2008, Vol 112, Issue 11, p2409
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/cncr.23453