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- Title
A novel pathway for Ca<sup>2+</sup> signalling in neutrophils by immune complexes.
- Authors
Davies, E. V.; Hallett, M. B.
- Abstract
The data presented here demonstrates that immune complexes use novel routes for stimulating a two-phase rise in cytosolic-free Ca2+ concentration. The initial transient Ca2+ rise resulted from release of Ca2+ from intracellular stores, by a route which, unlike f-met-leu-phe, was inhibited by bromophenacyl bromide. The second phase resulted from transmembrane influx and occurred in the absence of store release and by Ca2+ channels that were inhibited by Ni2+ but not SKF 96365 or econazole. Stimulation by immune complexes therefore involves novel routes for both the release of stored Ca2+ and the opening of Ca2+ channels in the plasma membrane.
- Subjects
NEUTROPHILS; GRANULOCYTES; PHAGOCYTES; IMMUNOGLOBULINS; CALCIUM; IMMUNE response
- Publication
Immunology, 1995, Vol 85, Issue 4, p538
- ISSN
0019-2805
- Publication type
Article