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- Title
Use of 99m Tc‐Mononuclear Leukocyte Scintigraphy in Nosocomial Fever.
- Authors
Gutfilen, B.; Lopes de Souza, S. A.; Martins, F. P. P.; Cardoso, L. R.; Pessoa, M. C. Pinheiro; Fonseca, L. M. B.
- Abstract
Purpose: To determine the overall diagnostic accuracy of mononuclear leukocyte‐ 99m Tc scintigraphy in the routine detection of infectious lesions and fever of unknown origin (FUO) in inpatients. Material and Methods: The use of mononuclear leukocyte 99m Tc scintigraphy is presented in 87 patients who fulfilled the Durack and Street diagnostic criteria of nosocomial FUO; 66 patients were suspected of having infectious lesions (myocarditis, endocarditis, infected catheters, diabetic foot, and osteomyelitis) and 21 patients presented with unknown causes of FUO. Scans were carried out 1, 3, and 24 h after injection of labeled leukocytes. Results: In three cases (3/27) where scintigraphs were negative, biopsies were positive. There were two (2/87) false‐positive scintigrams. We found a 95.8% sensitivity and 92.3% specificity. PPV was 93.8%, PPN 94.7%, and accuracy 94.2%. Conclusion: Mononuclear leukocyte 99m Tc scintigraphy showed high sensitivity, specificity, positive and negative predictive values in patients with nosocomial FUO. These results suggest an important role for nuclear medicine in the management of patients with infection/inflammation.
- Subjects
LEUCOCYTES; BLOOD cells; NOSOCOMIAL infections; IATROGENIC diseases; RADIONUCLIDE imaging; DIAGNOSTIC imaging; MEDICAL radiology
- Publication
Acta Radiologica, 2006, Vol 47, Issue 7, p699
- ISSN
0284-1851
- Publication type
Article
- DOI
10.1080/02841850600791526