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- Title
Sodium-Lithium Countertransport Activity in Healthy, Dyslipidemic, and Hypertensive Individuals.
- Authors
Savopoulos, Christos G.; Hatzitolios, Apostolos I.; Katsiki, Niki A.; Baltatzi, Maria; Kosmidou, Maria; Raikos, Nikolaos; Mikhailidis, Dimitri P.; Ziakas, Antonios G.; Kaiafa, Georgia; Tsesmeli, Niki
- Abstract
The aim of our study was to investigate the role of dyslipidemia on red blood cell sodium-lithium countertransport activity in healthy and hypertensive individuals. A total of 128 Caucasian individuals, aged 20 to 60 years old, were divided into 4 groups: dyslipidemic/ hypertensive, dyslipidemic/normotensive, normolipidemic/hypertensive, and normolipidemic/ normotensive (controls). Sodiumlithium countertransport activity was determined based on the Canessa et al method. Sodium-lithium countertransport activity was significantly higher in all patient groups compared with controls (P < .001) and similar in the 3 patient groups. Sodium-lithium countertransport activity was significantly and positively associated with triglyceride levels (P < .001), body mass index (P < .001), total cholesterol levels (P = .001), and systolic (P = .001) and diastolic blood pressure (P = .001). In multivariate regression analysis, triglycerides made the largest contribution to sodiumlithium countertransport variation among the variables tested (R[sup2] = 0.273). Our results suggest that dyslipidemia affects sodium-lithium countertransport activity independently of essential hypertension and even to a greater extent than hypertension.
- Subjects
BLOOD transfusion; HYPERTENSION; PATIENTS; ERYTHROCYTES; TRIGLYCERIDES; BLOOD pressure measurement; REGRESSION analysis
- Publication
Angiology, 2008, Vol 59, Issue 6, p727
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319708319784