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- Title
Determinants of Left Ventricular Function Two Weeks and One Year After an Acute Myocardial Infarction.
- Authors
Brzostek, Tomasz; van de Werf, Frans; Scheys, Ilse; Mortelmans, Luc; Aubert, André; Dubiel, Jacek S.; de Geest, Hilaire
- Abstract
This study examines possible covariates of left ventricular function two weeks and sixteen months after an acute infarction. It was performed in a group of 312 patients randomized double blindly to recombinant tissue plasminogen activator (rt-PA) (n=156) or placebo treatment and followed thereafter for at least one year. Two weeks after the infarction, enzymatic infarct size, infarct-related vessel, and number of diseased coronary arteries were significant determinants of the infarct-related regional wall motion (centerline method) (R²=0.25 to 0.60, P=0.0001). Enzymatic infarct size, regional wall motion of both infarct-related and remote areas, reinfarction, and treatment allocation were significant independent correlates of ejection fraction (R²=0.76), end-diastolic volume (R²=0.20), and end-systolic volume (R²=0.69, P < 0.0001). Infarct-related coronary artery and predischarge end-systolic volume were significant independent covariates of ejection fraction at rest (R²=0.47) after sixteen months. Age, enzymatic infarct size, and predischarge end-diastolic volume were independent determinants of the maximal (R²=0.49, P < 0.0001) and peak exercise ejection fraction (R²=0.49, P < 0.0001).
- Subjects
LEFT heart ventricle; MYOCARDIAL infarction; HEART diseases; PLASMINOGEN activators; CORONARY arteries; CARDIOLOGY
- Publication
Angiology, 1995, Vol 46, Issue 1, p27
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/000331979504600104